中文名 | Glucose-conjugated MGMT inhibitor |
英文名 | Glucose-conjugated MGMT inhibitor |
别名 | 化合物 T11419 MGMT抑制剂(GLUCOSE-CONJUGATED MGMT INHIBITOR) 8-[2-氨基-6-[(4-溴-2-噻吩基)甲氧基]-9H-嘌呤-9-基]辛基 BETA-D-吡喃葡萄糖苷 |
英文别名 | O6BTG-C8-βGlu O6BTG-octylglucoside Glucose-conjugated MGMT inhibitor β-D-Glucopyranoside, 8-[2-aMino-6-[(4-broMo-2-thienyl)Methoxy]-9H-purin-9-yl]octyl 8-[2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purin-9-yl]octyl beta-D-glucopyranoside (2R,3R,4S,5S,6R)-2-[8-[2-amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (2R,3R,4S,5S,6R)-2-((8-(2-aMino-6-((4-broMothiophen-2-yl)Methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol |
CAS | 382607-78-5 |
化学式 | C24H34BrN5O7S |
分子量 | 616.53 |
密度 | 1.70 |
沸点 | 847.4±75.0 °C(Predicted) |
溶解度 | 10毫米DMSO |
酸度系数 | 12.95±0.70(Predicted) |
存储条件 | -20℃ |
体外研究 | O6BTG-octylglucoside is a potent and non-toxic MGMT inhibitor, with IC 50 s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.622 ml | 8.11 ml | 16.22 ml |
5 mM | 0.324 ml | 1.622 ml | 3.244 ml |
10 mM | 0.162 ml | 0.811 ml | 1.622 ml |
5 mM | 0.032 ml | 0.162 ml | 0.324 ml |
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